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- Author:
- Eduardo Anitua
- María de la Fuente
- Francisco Muruzábal
- Jesús Merayo-Lloves
Short- and Long-Term Stability of Plasma Rich in Growth Factors Eye Drops
Cornea. 2021 Jan;40(1):107-112. To analyze whether plasma rich in growth factors (PRGFs) eye drops preserve their activity and biological properties after storage for 9 and 12 months at -20°C, and at 4°C, and at room temperature (RT) for 3 and 7 days in comparison to fresh samples (t0)
- Author:
- Eduardo Anitua
- Mohammad H. Alkhraisat
- Sofía Fernández de Retana
Platelet rich plasma in oral and maxillofacial surgery from the perspective of composition
Platelets. 2021 Feb 17;32(2):174-182. The application of platelet-rich plasma (PRP) in oral and maxillofacial surgery has been thoroughly studied in the last two decades. Currently, different types of PRP are applied in the clinical practice, being the presence or absence of leukocytes one of the classification criteria. However, there is poor evidence assessing the influence of the PRP composition in their efficacy.
- Author:
- Eduardo Anitua
- Suárez-Barrio C
- Del Olmo-Aguado S
- García-Pérez E
- Artime E
- de la Fuente M
- Muruzabal F
- Baamonde-Arbaiza B
- Fernández-Vega L
- Merayo-Lloves J.
Plasma Rich in Growth Factors Enhances Cell Survival after in Situ Retinal Degeneration
Int J Mol Sci. 2020 Oct 9;21(20):7442. The purpose of this study was to examine the effect of plasma rich in growth factors (PRGFs) under blue light conditions in an in vivo model of retinal degeneration.
- Author:
- Eduardo Anitua
- de la Fuente M
- Del Olmo-Aguado S
- Suarez-Barrio C
- Merayo-Lloves J
- Muruzabal F.
Plasma rich in growth factors reduces blue light-induced oxidative damage on retinal pigment epithelial cells and restores their homeostasis by modulating vascular endothelial growth factor and pigment epithelium-derived factor expression
Clin Exp Ophthalmol. 2020 Aug;48(6):830-838. This study analysed the effectiveness of plasma rich in growth factors (PRGF) in reducing the oxidative stress induced by blue light exposition on retinal pigment epithelial (RPE) cells.
- Author:
- Eduardo Anitua
- Suárez-Barrio C
- Del Olmo-Aguado S
- García-Pérez E
- de la Fuente M
- Muruzabal F
- Baamonde-Arbaiza B
- Fernández-Vega-Cueto L
- Fernández-Vega L
- Merayo-Lloves J.
Antioxidant Role of PRGF on RPE Cells after Blue Light Insult as a Therapy for Neurodegenerative Diseases
Int J Mol Sci. 2020 Feb 4;21(3):1021. Oxidative stress has a strong impact on the development of retinal diseases such as age-related macular degeneration (AMD). Plasma rich in growth factors (PRGF) is a novel therapeutic approach in ophthalmological pathologies. The aim of this study was to analyze the antioxidant effect of PRGF in retinal epithelial cells (EPR) in in vitro and ex vivo retinal phototoxicity models. In vitro analyses were performed on ARPE19 human cell line. Viability and mitochondrial status were assessed in order to test the primary effects of PRGF.
- Author:
- Sánchez-Ávila RM
- Fernández-Vega González Á
- Fernández-Vega Sanz Á
- Merayo-Lloves J
Treatment of recurrent myopic macular hole using membrane of plasma rich in growth factors
Int Med Case Rep J. 2019 Jul 12;12:229-233. To describe the case of a patient with a recurrent large myopic macular hole (MH), who was successfully treated with a plasma rich in growth factors (PRGF) membrane.
- Author:
- E. Bezuglov
- N. Maffulli
- A. Tokareva
- E. Achkasov
Platelet-rich plasma in hamstring muscle injuries in professional soccer players. A pilot study
Muscles, Ligaments and Tendons Journal 2019;9 (1) This study evaluated the efficacy of a single injection of Platelet-rich plasma (PRP) in the management of hamstring injuries (grade 2a and 2b according to the British Athletics Muscle Injury Classification) in professional soccer players.
- Author:
- Eduardo Anitua
- Muruzábal F
- Riestra A
- De la Fuente M
- Merayo-Lloves J
Galenic validation of plasma rich in growth factors eye drops
Farm Hosp. 2019 Mar 1;43(2):45-49. Galenic evaluation of the process for obtaining and storing the platelet rich in growth factors PRGF-Endoret® eye drops.
- Author:
- Eduardo Anitua
- Piñas L
- Alkhraisat MH
- Fernández RS
Biological Therapy of Refractory Ulcerative Oral Lichen Planus with Plasma Rich in Growth Factors
Am J Clin Dermatol. 2017 Jun;18(3):429-433.
- Author:
- Riestra AC
- Alonso-Herreros JM
- Merayo-Lloves J
Platelet rich plasma in ocular surface
Arch Soc Esp Oftalmol. 2016 Oct;91(10):475-90. The use of platelet-rich preparations has experienced a significant increase in recent years due to its role in tissue-repair and regeneration. The aim of this study is to examine the available evidence regarding the application of plasma rich in growth factors, and its variations, on the ocular surface. A review is also presented on the effects of platelet-derived growth factors, the implications of the preparation methods, and the existing literature on the safety and efficacy of these therapies in ocular surface diseases. Despite the widespread use of platelet preparations there is no consensus on the most appropriate preparation method, and growth factors concentration vary with different systems. These preparations have been used in the treatment of ocular surface diseases, such as dry eye or persistent epithelial defects, among others, with good safety and efficacy profiles, but further studies are needed to compare to the currently available alternatives.