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- Autore:
- Eduardo Anitua
- Pino A
- Alkhraisat MH
Efficacy of Plasma Rich in Growth Factors for Healing Chronic Skin Ulcers: A Systematic Review of Randomized Controlled Trials With Meta-Analysis
Chronic skin ulceration is a serious pathological condition for which the adjuvant use of platelet-rich plasma (PRP) has been indicated. However, evidence for the use of PRP in patients with chronic skin ulcers remains insufficient due to a large heterogeneity in experimental designs, PRP composition, and preparation protocols.
- Autore:
- Eduardo Anitua
- Zalduendo M
- Tierno R
- Alkhraisat MH
Plasma Rich in Growth Factors in Bone Regeneration: The Proximity to the Clot as a Differential Factor in Osteoblast Cell Behaviour
The osteogenic differentiation process, by which bone marrow mesenchymal stem cells and osteoprogenitors transform into osteoblasts, is regulated by several growth factors, cytokines, and hormones. Plasma Rich in Growth Factors (PRGF) is a blood-derived preparation consisting of a plethora of bioactive molecules, also susceptible to containing epigenetic factors such as ncRNAs and EVs, that stimulates tissue regeneration. The aim of this study was to investigate the effect of the PRGF clot formulation on osteogenic differentiation. Firstly, osteoblast cells were isolated and characterised. The proliferation of bone cells cultured onto PRGF clots or treated with PRGF supernatant was determined.
- Autore:
- Eduardo Anitua
- Troya M
- Zalduendo M
- Tierno R
- Alkhraisat MH
- Osinalde N
- Fullaondo A
- Zubiaga AM
Improving the mechanical and biological functions of cell sheet constructs: The interplay of human-derived periodontal ligament stem cells, endothelial cells and plasma rich in growth factors
The aim of this study was to produce and characterize triple-layered cell sheet constructs with varying cell compositions combined or not with the fibrin membrane scaffold obtained by the technology of Plasma Rich in Growth Factors (mPRGF).
- Autore:
- Eduardo Anitua
- Lozano-Sanroma J
- Barros A
- Alcalde I
- Alvarado-Villacorta R
- Sánchez-Ávila RM
- Queiruga-Piñeiro J
- Cueto LF
- Merayo-Lloves J
Efficacy and Safety of Plasma Rich in Growth Factor in Patients with Congenital Aniridia and Dry Eye Disease
Congenital aniridia is a rare bilateral ocular malformation characterized by the partial or complete absence of the iris and is frequently associated with various anomalies, including keratopathy, cataract, glaucoma, and foveal and optic nerve hypoplasia. Additionally, nearly 50% of individuals with congenital aniridia experience symptoms of ocular dryness. Traditional treatment encompasses artificial tears and autologous serum. This study aimed to assess the effectiveness and safety of using platelet rich in growth factors (PRGF) plasma in patients with congenital aniridia and ocular dryness symptoms.
- Autore:
- Eduardo Anitua
- Ricardo Tejero
- Romero Gavilán F
- Cerqueira A
- Muñoz F
- García Arnáez I
- Azkargorta M
- Elortza F
- Gurruchaga M
- Goñi I
- Suay J
Enhancing the correlation between in vitro and in vivo experiments in dental implant osseointegration: investigating the role of Ca ions
This study delves into the osteogenic potential of a calcium-ion modified titanium implant surface, unicCa, employing state-of-the-art proteomics techniques both in vitro (utilizing osteoblasts and macrophage cell cultures) and in vivo (in a rabbit condyle model). When human osteoblasts (Hobs) were cultured on unicCa surfaces, they displayed a marked improvement in cell adhesion and differentiation compared to their unmodified counterparts. The proteomic analysis also revealed enrichment in functions associated with cell migration, adhesion, extracellular matrix organization, and proliferation.
- Autore:
- Eduardo Anitua
- Ander Pino
- Prado R
- Muruzabal F
- Alkhraisat MH
Biochemical and biomechanical characterization of an autologous protein-based fibrin sealant for regenerative medicine
Accidental events or surgical procedures usually lead to tissue injury. Fibrin sealants have proven to optimize the healing process but have some drawbacks due to their allogeneic nature. Autologous fibrin sealants present several advantages. The aim of this study is to evaluate the performance of a new autologous fibrin sealant based on Endoret®PRGF® technology (E-sealant). One of the most widely used commercial fibrin sealants (Tisseel®) was included as comparative Control.
- Autore:
- Eduardo Anitua
- Ander Pino
- Muruzabal F
- Prado R
- Tierno R
- Persinal-Medina M
- Alkhraisat MH
- Merayo-Lloves J
Biological and Adhesive Properties of an Autologous Protein-Based Fibrin Sealant for Ophthalmological Applications
The aim of this study was to evaluate the biological and adhesive properties of a new autologous sealant based on plasma rich in growth factors (PRGF), named E-Sealant.
- Autore:
- Eduardo Anitua
- Milani I
- Martinez A
- Cabello F
- Prado R
- Padilla S
- Sanado L
Plasma Rich in Growth Factors (PRGF) in the Treatment of Patients With Chronic Cervical and Lumbar Pain: A Prospective Observational Clinical Study
The aim of our study was to assess the efficacy of intradiscal and epidural injections of plasma rich in growth factors (PRGF) in patients with chronic clinical symptoms due to intervertebral disc (IVD) degeneration.
- Autore:
- Eduardo Anitua
- Diez GG
- Castellanos N
- Vázquez C
- Galindo-Villardón P
- Alkhraisat MH
The effect of mindfulness on the inflammatory, psychological and biomechanical domains of adult patients with low back pain: A randomized controlled clinical trial
Narrow dental implants are commonly used to restore narrow alveolar ridges. Although the good performance of narrow dental implants supporting multiple prostheses has been repeatedly demonstrated, there are few studies analyzing their performance in a long-term follow-up together with the influence of the loading protocol. Thus, the objective was to assess the influence of implant loading protocol (immediate vs delayed) on the long-term outcomes of 3.0-mm-diameter dental implants supporting fixed multiple prostheses.
- Autore:
- Eduardo Anitua
- Asier Eguia
- Allende M
- Alkhraisat MH
Bone-Regenerative Ability of Platelet-Rich Plasma Following Sinus Augmentation with Anorganic Bovine Bone: A Systematic Review with Meta-Analysis
The objective of this systematic review is to assess the effect of the adjuvant use of platelet-rich plasma (PRP) and its type on new bone formation by anorganic bovine bone during maxillary sinus floor augmentation procedure