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- Autor:
- Eduardo Anitua
- Mohammad H. Alkhraisat
- Mar Zalduendo
- María Troya
- Roberto Tierno
The inclusion of leukocytes into platelet rich plasma reduces scaffold stability and hinders extracellular matrix remodelling
Scaffolds should have controllable degradation rate and allow cells to produce their own extracellular matrix. Platelet rich plasma (PRP) is a source of autologous growth factors and proteins embedded in a 3D fibrin scaffold. There is no consensus regarding the obtaining conditions and composition of PRPs.
- Autor:
- Eduardo Anitua
- Ronald M Sánchez-Ávila
- Carlos A Robayo-Esper
- Eva Villota-Deleu
- Álvaro Fernández-Vega Sanz
- Álvaro Fernández-Vega González
- Borja de la Sen-Corcuera
- Jesús Merayo-Lloves
Plasma Rich in Growth Factors in Macular Hole Surgery
The aim of this study was to evaluate the use of PRGF (plasma rich in growth factors) as an adjuvant to PPV (pars plana vitrectomy) in recurrent, persistent, or poor prognosis MH (macular hole). Patients with MH were treated with PPV plus adjuvant therapy (PRGF membrane (mPRGF) and injectable liquid PRGF (iPRGF)).
- Autor:
- Eduardo Anitua
- Ander Pino
- Victoria Muñoz
- Libe Aspe
- Roberto Tierno
- Adrian García-Salvador
- Felipe Goñi-de-Cerio
In vitro and in vivo Effect of Platelet-Rich Plasma-Based Autologous Topical Serum on Cutaneous Wound Healing
Skin injury and wound healing is an inevitable event during lifetime. However, several complications may hamper the regeneration of the cutaneous tissue and lead to a chronic profile that prolongs patient recovery. Platelet-rich plasma is rising as an effective and safe alternative to the management of wounds
- Autor:
- Eduardo Anitua
- Gorka Orive
- Miriam Idoipe
- Borja de la Sen-Corcuera
- Ronald M Sánchez-Ávila
- Carmen Sánchez-Pérez
- María Satué
- Antonio Sánchez-Pérez
- Francisco Muruzabal
- Luis Pablo
Membrane of Plasma Rich in Growth Factors in Primary Pterygium Surgery Compared to Amniotic Membrane Transplantation and Conjunctival Autograft
This prospective and comparative study aimed to compare the use of a conjunctival autograft (CAG), plasma rich in growth factors fibrin membrane (mPRGF) or amniotic membrane transplantation (AMT) in primary pterygium surgery.
- Autor:
- Eduardo Anitua
- Mohammad H. Alkhraisat
- María Troya
- Roberto Tierno
- Mar Zalduendo
The Effectiveness of Platelet-Rich Plasma as a Carrier of Stem Cells in Tissue Regeneration: A Systematic Review of Pre-Clinical Research
Fibrin, as a physiological scaffold, presents many advantages compared to synthetic materials, such as controllable degradation, non-toxic byproducts, and excellent biocompatibility. The use of stem cells along with the biomimicking scaffolds and signalling factors would complete the triad of the tissue engineering approach
- Autor:
- Eduardo Anitua
- Sabino Padilla
- Alan T Nurden
- Roberto Prado
- Paquita Nurden
Healing through the lens of immunothrombosis: Biology-inspired, evolution-tailored, and human-engineered biomimetic therapies
Evolution, from invertebrates to mammals, has yielded and shaped immunoclotting as a defense and repair response against trauma and infection. This mosaic of immediate and local wound-sealing and pathogen-killing mechanisms results in survival, restoration of homeostasis, and tissue repair.
- Autor:
- Eduardo Anitua
- Ander Pino
- Francisco Muruzabal
- Roberto Prado
- Mikel Azkargorta
- Felix Elortza
- Jesús Merayo-Lloves
Proteomic Characterization of Plasma Rich in Growth Factors and Undiluted Autologous Serum
Over the last three decades, there has been special interest in developing drugs that mimic the characteristics of natural tears for use it in the treatment of several ocular surface disorders. Interestingly, the composition of blood plasma is very similar to tears. Therefore, different blood-derived products like autologous serum (AS) and plasma rich in growth factors (PRGF) have been developed for the treatment of diverse ocular pathologies.
- Autor:
- Eduardo Anitua
- Fernando Kirchner
- Isidro Milani
- Alex Martinez
- Nicolas Kirchner-Bossi
- Roberto Prado
- Sabino Padilla
Plasma Rich in Growth Factors (PRGF) in the Treatment of Cervical and Lumbar Back Pain: A Retrospective Observational Clinical Study
Plasma rich in growth factors (PRGF) is a leukocyte-free platelet-rich plasma (PRP) that is an effective biological approach to tissue repair and has been demonstrated to significantly improve multiple conditions, including low back pain and degenerative disc pathology
- Autor:
- Eduardo Anitua
- Ander Pino
- Victoria Muñoz
- Carmen Martinez
- Begoña Echevarria
- Varlan Lacramioara
An Autologous Protein-Based Topical Ointment for Hard-to-Heal Skin Wounds: A Multiple Case Series
There is increasing evidence regarding the wound healing potential of platelet-derived autologous by-products. We provide preliminary data regarding the use of a new plasma rich in growth factors-derived autologous topical ointment for the management of hard-to-heal wounds
- Autor:
- Eduardo Anitua
- Gorka Orive
- B de la Sen Corcuera
- R M Sánchez Ávila
- P Heredia
- F Muruzabal
- J Merayo-Lloves
Progress in the use of plasma rich in growth factors in ophthalmology: from ocular surface to ocular fundus
The use of blood derivatives and especially Plasma rich in growth factors (PRGF), for regenerative purposes has been a common trend along the last decades in the field of oral surgery, dermatology, orthopedics, and more recently in ophthalmology.