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Articles of Regenerative medicine

  • Author:
  • Eduardo Anitua
  • Mohammad H. Alkhraisat
  • Mar Zalduendo
  • María Troya
  • Roberto Tierno

Scaffolds should have controllable degradation rate and allow cells to produce their own extracellular matrix. Platelet rich plasma (PRP) is a source of autologous growth factors and proteins embedded in a 3D fibrin scaffold. There is no consensus regarding the obtaining conditions and composition of PRPs.

  • Author:
  • Eduardo Anitua
  • Ronald M Sánchez-Ávila
  • Carlos A Robayo-Esper
  • Eva Villota-Deleu
  • Álvaro Fernández-Vega Sanz
  • Álvaro Fernández-Vega González
  • Borja de la Sen-Corcuera
  • Jesús Merayo-Lloves

The aim of this study was to evaluate the use of PRGF (plasma rich in growth factors) as an adjuvant to PPV (pars plana vitrectomy) in recurrent, persistent, or poor prognosis MH (macular hole). Patients with MH were treated with PPV plus adjuvant therapy (PRGF membrane (mPRGF) and injectable liquid PRGF (iPRGF)).

Skin injury and wound healing is an inevitable event during lifetime. However, several complications may hamper the regeneration of the cutaneous tissue and lead to a chronic profile that prolongs patient recovery. Platelet-rich plasma is rising as an effective and safe alternative to the management of wounds

  • Author:
  • Eduardo Anitua
  • Gorka Orive
  • Miriam Idoipe
  • Borja de la Sen-Corcuera
  • Ronald M Sánchez-Ávila
  • Carmen Sánchez-Pérez
  • María Satué
  • Antonio Sánchez-Pérez
  • Francisco Muruzabal
  • Luis Pablo

This prospective and comparative study aimed to compare the use of a conjunctival autograft (CAG), plasma rich in growth factors fibrin membrane (mPRGF) or amniotic membrane transplantation (AMT) in primary pterygium surgery.

  • Author:
  • Eduardo Anitua
  • María Troya
  • Roberto Tierno
  • Mar Zalduendo
  • Mohammad H. Alkhraisat

Fibrin, as a physiological scaffold, presents many advantages compared to synthetic materials, such as controllable degradation, non-toxic byproducts, and excellent biocompatibility. The use of stem cells along with the biomimicking scaffolds and signalling factors would complete the triad of the tissue engineering approach

  • Author:
  • Eduardo Anitua
  • Sabino Padilla
  • Alan T Nurden
  • Roberto Prado
  • Paquita Nurden

Evolution, from invertebrates to mammals, has yielded and shaped immunoclotting as a defense and repair response against trauma and infection. This mosaic of immediate and local wound-sealing and pathogen-killing mechanisms results in survival, restoration of homeostasis, and tissue repair.

Over the last three decades, there has been special interest in developing drugs that mimic the characteristics of natural tears for use it in the treatment of several ocular surface disorders. Interestingly, the composition of blood plasma is very similar to tears. Therefore, different blood-derived products like autologous serum (AS) and plasma rich in growth factors (PRGF) have been developed for the treatment of diverse ocular pathologies.

  • Author:
  • Eduardo Anitua
  • Fernando Kirchner
  • Isidro Milani
  • Alex Martinez
  • Nicolas Kirchner-Bossi
  • Roberto Prado
  • Sabino Padilla

Plasma rich in growth factors (PRGF) is a leukocyte-free platelet-rich plasma (PRP) that is an effective biological approach to tissue repair and has been demonstrated to significantly improve multiple conditions, including low back pain and degenerative disc pathology