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Regenerative medicine

Efficacy of Plasma Rich in Growth Factors for Healing Chronic Skin Ulcers: A Systematic Review of Randomized Controlled Trials With Meta-Analysis
PMID: 39018362

Wounds. 2024 Jun;36(6):189-200. Chronic skin ulceration is a serious pathological condition for which the adjuvant use of platelet-rich plasma (PRP) has been indicated. However, evidence for the use of PRP in patients with chronic skin ulcers remains insufficient due to a large heterogeneity in experimental designs, PRP composition, and preparation protocols.

Improving the mechanical and biological functions of cell sheet constructs: The interplay of human-derived periodontal ligament stem cells, endothelial cells and plasma rich in growth factors
  • Author:
  • Eduardo Anitua
  • Troya M
  • Zalduendo M
  • Tierno R
  • Alkhraisat MH
  • Osinalde N
  • Fullaondo A
  • Zubiaga AM
PMID: 36520117

Biomed Pharmacother. 2024 May:174:116599. The aim of this study was to produce and characterize triple-layered cell sheet constructs with varying cell compositions combined or not with the fibrin membrane scaffold obtained by the technology of Plasma Rich in Growth Factors (mPRGF).

Efficacy and Safety of Plasma Rich in Growth Factor in Patients with Congenital Aniridia and Dry Eye Disease
  • Author:
  • Eduardo Anitua
  • Lozano-Sanroma J
  • Barros A
  • Alcalde I
  • Alvarado-Villacorta R
  • Sánchez-Ávila RM
  • Queiruga-Piñeiro J
  • Cueto LF
  • Merayo-Lloves J
PMID: 38667534

Diseases. 2024 Apr 11;12(4):76. Congenital aniridia is a rare bilateral ocular malformation characterized by the partial or complete absence of the iris and is frequently associated with various anomalies, including keratopathy, cataract, glaucoma, and foveal and optic nerve hypoplasia. Additionally, nearly 50% of individuals with congenital aniridia experience symptoms of ocular dryness. Traditional treatment encompasses artificial tears and autologous serum. This study aimed to assess the effectiveness and safety of using platelet rich in growth factors (PRGF) plasma in patients with congenital aniridia and ocular dryness symptoms.

Enhancing the correlation between in vitro and in vivo experiments in dental implant osseointegration: investigating the role of Ca ions
PMID: 38412455

J Mater Chem B. 2024 Mar 13;12(11):2831-2842. This study delves into the osteogenic potential of a calcium-ion modified titanium implant surface, unicCa, employing state-of-the-art proteomics techniques both in vitro (utilizing osteoblasts and macrophage cell cultures) and in vivo (in a rabbit condyle model). When human osteoblasts (Hobs) were cultured on unicCa surfaces, they displayed a marked improvement in cell adhesion and differentiation compared to their unmodified counterparts. The proteomic analysis also revealed enrichment in functions associated with cell migration, adhesion, extracellular matrix organization, and proliferation.

Biochemical and biomechanical characterization of an autologous protein-based fibrin sealant for regenerative medicine
PMID: 38456966

J Mater Sci Mater Med. 2024 Mar 8;35(1):15 Accidental events or surgical procedures usually lead to tissue injury. Fibrin sealants have proven to optimize the healing process but have some drawbacks due to their allogeneic nature. Autologous fibrin sealants present several advantages. The aim of this study is to evaluate the performance of a new autologous fibrin sealant based on Endoret®PRGF® technology (E-sealant). One of the most widely used commercial fibrin sealants (Tisseel®) was included as comparative Control.

Plasma Rich in Growth Factors (PRGF) in the Treatment of Patients With Chronic Cervical and Lumbar Pain: A Prospective Observational Clinical Study
  • Author:
  • Eduardo Anitua
  • Milani I
  • Martinez A
  • Cabello F
  • Prado R
  • Padilla S
  • Sanado L
PMID: 37847927

Pain Physician. 2023 Oct;26(6):E725-E736. The aim of our study was to assess the efficacy of intradiscal and epidural injections of plasma rich in growth factors (PRGF) in patients with chronic clinical symptoms due to intervertebral disc (IVD) degeneration.

Bone-Regenerative Ability of Platelet-Rich Plasma Following Sinus Augmentation with Anorganic Bovine Bone: A Systematic Review with Meta-Analysis
PMID: 36290564

Bioengineering (Basel). 2022 Oct 21;9(10):597. The objective of this systematic review is to assess the effect of the adjuvant use of platelet-rich plasma (PRP) and its type on new bone formation by anorganic bovine bone during maxillary sinus floor augmentation procedure