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- Author:
- Eduardo Anitua
- Antonio Ríos
- Homid Fahandezh-Saddi Díaz
- Manuel Villanueva Martinez
- Roberto Prado
- Sabino Padilla
Office-Based Intraosseous Infiltrations of PRGF in Knee Osteoarthritis: Description of Technique
Arthrosc Tech. 2022 Apr 25;11(5):e917-e921. The application of the counter-torque technique has been proposed as a conservative and atraumatic alternative for the explantation of nonmobile dental implants. The objective of this report is to assess the performance of this technique in a large number of patients.
- Author:
- Rangel CM
- Blanco NA
- Pedraza-Concha A
- Gomez MA
- Parra MM
- Arias JD
Plasma rich in growth factors as treatment for a full-thickness macular hole due to macular telangiectasia type 2
Arch Soc Esp Oftalmol (Engl Ed). 2022 Apr;97(4):219-223. Full-thickness macular hole is a rare complication of macular telangiectasia type 2, and its treatment is still controversial. A patient with a full-thickness macular hole secondary to macular telangiectasia type 2 underwent vitreoretinal surgery with a plasma rich in growth factors membrane in the macular hole. At the sixth month of follow-up, anatomical and functional improvements were achieved, with no adverse effects.
- Author:
- Arias JD
- Hoyos AT
- Alcántara B
- Sanchez-Avila RM
- Arango FJ
- Galvis V
Plasma Rich in Growth Factors for Persistent Macular Hole: A Pilot Study
Retin Cases Brief Rep. 2022 Mar 1;16(2):155-160. Persistent macular hole (PMH) is a challenge for retina surgeons. There are limited surgical techniques described achieving PMH closure. For more than a decade, techniques with blood derivatives have been described without optimal outcomes. The aim of this article is to report the usefulness of the plasma rich in growth factors (PRGF) as a new way to improve PMH closure.
- Author:
- Eduardo Anitua
- Mohammad H. Alkhraisat
- Mar Zalduendo
- María Troya
- Roberto Tierno
The inclusion of leukocytes into platelet rich plasma reduces scaffold stability and hinders extracellular matrix remodelling
Ann Anat. 2022 Feb:240:151853. doi: 10.1016/j.aanat.2021.151853. Scaffolds should have controllable degradation rate and allow cells to produce their own extracellular matrix. Platelet rich plasma (PRP) is a source of autologous growth factors and proteins embedded in a 3D fibrin scaffold. There is no consensus regarding the obtaining conditions and composition of PRPs.
- Author:
- Eduardo Anitua
- Ronald M Sánchez-Ávila
- Carlos A Robayo-Esper
- Eva Villota-Deleu
- Álvaro Fernández-Vega Sanz
- Álvaro Fernández-Vega González
- Borja de la Sen-Corcuera
- Jesús Merayo-Lloves
Plasma Rich in Growth Factors in Macular Hole Surgery
Clin Pract. 2022 Jan 10;12(1):57-69. The aim of this study was to evaluate the use of PRGF (plasma rich in growth factors) as an adjuvant to PPV (pars plana vitrectomy) in recurrent, persistent, or poor prognosis MH (macular hole). Patients with MH were treated with PPV plus adjuvant therapy (PRGF membrane (mPRGF) and injectable liquid PRGF (iPRGF)).
- Author:
- Eduardo Anitua
- Ander Pino
- Victoria Muñoz
- Libe Aspe
- Roberto Tierno
- Adrian García-Salvador
- Felipe Goñi-de-Cerio
In vitro and in vivo Effect of Platelet-Rich Plasma-Based Autologous Topical Serum on Cutaneous Wound Healing
Skin Pharmacol Physiol. 2022;35(1):51-64. Skin injury and wound healing is an inevitable event during lifetime. However, several complications may hamper the regeneration of the cutaneous tissue and lead to a chronic profile that prolongs patient recovery. Platelet-rich plasma is rising as an effective and safe alternative to the management of wounds
- Author:
- Eduardo Anitua
- Gorka Orive
- Miriam Idoipe
- Borja de la Sen-Corcuera
- Ronald M Sánchez-Ávila
- Carmen Sánchez-Pérez
- María Satué
- Antonio Sánchez-Pérez
- Francisco Muruzabal
- Luis Pablo
Membrane of Plasma Rich in Growth Factors in Primary Pterygium Surgery Compared to Amniotic Membrane Transplantation and Conjunctival Autograft
J Clin Med. 2021 Dec 6;10(23):5711. This prospective and comparative study aimed to compare the use of a conjunctival autograft (CAG), plasma rich in growth factors fibrin membrane (mPRGF) or amniotic membrane transplantation (AMT) in primary pterygium surgery.
- Author:
- Eduardo Anitua
- María Troya
- Roberto Tierno
- Mar Zalduendo
- Mohammad H. Alkhraisat
The Effectiveness of Platelet-Rich Plasma as a Carrier of Stem Cells in Tissue Regeneration: A Systematic Review of Pre-Clinical Research
Cells Tissues Organs. 2021;210(5-6):339-350. Fibrin, as a physiological scaffold, presents many advantages compared to synthetic materials, such as controllable degradation, non-toxic byproducts, and excellent biocompatibility. The use of stem cells along with the biomimicking scaffolds and signalling factors would complete the triad of the tissue engineering approach
- Author:
- Eduardo Anitua
- Sabino Padilla
- Alan T Nurden
- Roberto Prado
- Paquita Nurden
Healing through the lens of immunothrombosis: Biology-inspired, evolution-tailored, and human-engineered biomimetic therapies
Biomaterials. 2021 Dec:279:121205. Evolution, from invertebrates to mammals, has yielded and shaped immunoclotting as a defense and repair response against trauma and infection. This mosaic of immediate and local wound-sealing and pathogen-killing mechanisms results in survival, restoration of homeostasis, and tissue repair.
- Author:
- Eduardo Anitua
- Ander Pino
- Francisco Muruzabal
- Roberto Prado
- Mikel Azkargorta
- Felix Elortza
- Jesús Merayo-Lloves
Proteomic Characterization of Plasma Rich in Growth Factors and Undiluted Autologous Serum
Int J Mol Sci. 2021 Nov 10;22(22):12176. Over the last three decades, there has been special interest in developing drugs that mimic the characteristics of natural tears for use it in the treatment of several ocular surface disorders. Interestingly, the composition of blood plasma is very similar to tears. Therefore, different blood-derived products like autologous serum (AS) and plasma rich in growth factors (PRGF) have been developed for the treatment of diverse ocular pathologies.