Regenerative medicine

Clin Exp Ophthalmol. 2020 Aug;48(6):830-838. This study analysed the effectiveness of plasma rich in growth factors (PRGF) in reducing the oxidative stress induced by blue light exposition on retinal pigment epithelial (RPE) cells.

Int J Mol Sci. 2020 Feb 4;21(3):1021. Oxidative stress has a strong impact on the development of retinal diseases such as age-related macular degeneration (AMD). Plasma rich in growth factors (PRGF) is a novel therapeutic approach in ophthalmological pathologies. The aim of this study was to analyze the antioxidant effect of PRGF in retinal epithelial cells (EPR) in in vitro and ex vivo retinal phototoxicity models. In vitro analyses were performed on ARPE19 human cell line. Viability and mitochondrial status were assessed in order to test the primary effects of PRGF.

Eur J Ophthalmol. 2019 Nov;29(6):654-658. Central graft ulceration is a rare complication of an orbital dermal fat graft caused by diminished blood supply to the implant. This study reports on the efficacy and safety of the use of a single subconjunctival injection of autologous platelet-rich plasma to rescue an ulcerated orbital dermal fat graft.

Int Med Case Rep J. 2019 Jul 12;12:229-233. To describe the case of a patient with a recurrent large myopic macular hole (MH), who was successfully treated with a plasma rich in growth factors (PRGF) membrane.

Muscles, Ligaments and Tendons Journal 2019;9 (1) This study evaluated the efficacy of a single injection of Platelet-rich plasma (PRP) in the management of hamstring injuries (grade 2a and 2b according to the British Athletics Muscle Injury Classification) in professional soccer players.

Farm Hosp. 2019 Mar 1;43(2):45-49. Galenic evaluation of the process for obtaining and storing the platelet rich in growth factors PRGF-Endoret® eye drops.

Ophthalmic Res. 2018;59(1):45-52. To evaluate the potential role of the autologous PRGF (plasma rich in growth factors) fibrin membrane in tissue regeneration after glaucoma filtering surgery.

Int Med Case Rep J. 2018 May 1;11:97-103. To evaluate the efficacy and safety of plasma rich in growth factors (PRGF) eye drops in patients with glaucoma with secondary ocular surface disorders (OSDs) due to surgeries and topical hypotensive drugs use.

Medicine (Baltimore). 2018 Apr;97(17):e0242. To evaluate the safety and efficacy of the surgical use of plasma rich in growth factors fibrin membrane (mPRGF) in different ocular surface pathologies.Fifteen patients with different corneal and conjunctival diseases were included in the study. Patients were grouped according to the use of mPRGF as graft (corneal and/or conjunctival) or dressing; they were also grouped according to the surgical subgroup of intervention (persistent corneal ulcer [PCU], keratoplasty, superficial keratectomy, corneal perforation, and pterygium).

Ocul Surf. 2017 Apr;15(2):248-256. Develop an autologous culture method for ex vivo expansion of human limbal epithelial progenitor cells (LEPCs) using Plasma Rich in Growth Factors (PRGF) as a growth supplement and as a scaffold for the culture of LEPCs.