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Eduardo Anitua_fondo

Eduardo Anitua

MD, DDS, PhD

Director of the Eduardo Anitua Institute, a basic and applied research institute and a clinical and training center in oral implantology and regenerative therapy. Scientific director of BTI (Biotechnology Institute).

Degree in Medicine and Surgery from the University of Salamanca. PhD in Medicine and Surgery from the University of Valencia. Specialised in Stomatology from the University of the Basque Country. Honorary Degree at the University of Buenos Aires (UBA).

He combines scientific research as the founder and Scientific Director of BTI Biotechnology Institute with work at a private clinic, as well as directing the University Institute for Regenerative Medicine and Oral Implantology at the University of the Basque Country (UPV/EHU) and presiding over the foundation which bears his name.

He is guest lecturer at over 50 universities and has taught over 500 courses and lectures on oral implantology and regenerative medicine at national and international conferences.

He holds 53 international patents and is the author of over 200 scientific articles published in indexed journals, several hundreds more in clinical journals, as well as over 20 books and surgical manuals covering different areas of medicine.

Dr. Eduardo Anitua is considered to be one of the world leaders in the field of regenerative medicine as he is the pioneer of one of the most relevant translational therapies of the last decades, known as plasma rich in growth factors Endoret® (PRGF®) technology.

Courses taught

Published Articles

Macrophages are innate immune cells that display remarkable phenotypic heterogeneity and functional plasticity. Due to their involvement in the pathogenesis of several human conditions, macrophages are considered to be an attractive therapeutic target. In line with this, platelet derivatives have been successfully applied in many medical fields and as active participants in innate immunity, cooperation between platelets and macrophages is essential. In this context, the aim of this review is to compile the current evidence regarding the effects of platelet derivatives on the phenotype and functions of macrophages to identify the advantages and shortcomings for feasible future clinical applications.

Wounds. 2024 Jun;36(6):189-200. Chronic skin ulceration is a serious pathological condition for which the adjuvant use of platelet-rich plasma (PRP) has been indicated. However, evidence for the use of PRP in patients with chronic skin ulcers remains insufficient due to a large heterogeneity in experimental designs, PRP composition, and preparation protocols.

There is a lack of consensus on managing resultant bone and soft tissue defects or on restoring oral function and aesthetics following medication-related osteonecrosis of the jaws (MRONJ) lesion healing. This clinical challenge presents a dilemma for practitioners. Removable prostheses pose a recurrence risk if poorly fitted and may inadequately restore function or aesthetics in cases of significant bone defect. Dental implant-supported prostheses could enhance function and quality of life, though their risks and indications are not well-defined. This systematic review examines the clinical outcomes and complications associated with implant-supported rehabilitations post-MRONJ surgery. This study was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement recommendations and it was pre-registered in the Prospective Register of Systematic Reviews (PROSPERO) (CRD42023492539).

Dent J (Basel). 2024 Apr 24;12(5):122. The osteogenic differentiation process, by which bone marrow mesenchymal stem cells and osteoprogenitors transform into osteoblasts, is regulated by several growth factors, cytokines, and hormones. Plasma Rich in Growth Factors (PRGF) is a blood-derived preparation consisting of a plethora of bioactive molecules, also susceptible to containing epigenetic factors such as ncRNAs and EVs, that stimulates tissue regeneration. The aim of this study was to investigate the effect of the PRGF clot formulation on osteogenic differentiation. Firstly, osteoblast cells were isolated and characterised. The proliferation of bone cells cultured onto PRGF clots or treated with PRGF supernatant was determined.

  • Author:
  • Eduardo Anitua
  • Troya M
  • Zalduendo M
  • Tierno R
  • Alkhraisat MH
  • Osinalde N
  • Fullaondo A
  • Zubiaga AM

Biomed Pharmacother. 2024 May:174:116599. The aim of this study was to produce and characterize triple-layered cell sheet constructs with varying cell compositions combined or not with the fibrin membrane scaffold obtained by the technology of Plasma Rich in Growth Factors (mPRGF).

Videos available on BTI Channel

In addition to this small sample, on BTI Channel you can increase your knowledge about oral implantology, regenerative medicine and sleep apnoea.

Eduardo Anitua
Treatment of post-extraction socket in aesthetic zone
Eduardo Anitua
Narrow Ridges: Selection of the implant and number of implants