Background: This study evaluated the efficacy of a single injection of Platelet-rich plasma (PRP) in the management of hamstring injuries (grade 2a and 2b according to the British Athletics Muscle Injury Classification) in professional soccer players.

Methods: Forty professional male soccer players with an acute hamstring injury, verified by MRI, were randomly treated either conservatively (physiotherapy, exercises) or with a combination of conservative methods and injections of PRP.

Results: The time to return to sport (RTS) in the PRP group (11.4 ± 1.2 days) was significantly shorter than in the other group (21.3 ± 2.7 days; p < 0.05). There were no episodes of reinjury in both groups at a minimum of 6 months of follow-up.