{"id":40436,"date":"2023-07-06T12:59:42","date_gmt":"2023-07-06T11:59:42","guid":{"rendered":"https:\/\/www.btitrainingcenter.com\/office-based-intraosseous-infiltrations-of-prgf-as-an-effective-treatment-for-knee-osteoarthritis-a-retrospective-observational-clinical-study\/"},"modified":"2025-07-11T15:45:18","modified_gmt":"2025-07-11T14:45:18","slug":"office-based-intraosseous-infiltrations-of-prgf-as-an-effective-treatment-for-knee-osteoarthritis-a-retrospective-observational-clinical-study","status":"publish","type":"post","link":"https:\/\/www.btitrainingcenter.com\/pt-pt\/office-based-intraosseous-infiltrations-of-prgf-as-an-effective-treatment-for-knee-osteoarthritis-a-retrospective-observational-clinical-study\/","title":{"rendered":"Office-Based Intraosseous Infiltrations of PRGF as an Effective Treatment for Knee Osteoarthritis: A Retrospective Observational Clinical Study"},"content":{"rendered":"

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Abstract<\/h3>\n
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The aim of this study was to explore and assess office-based ultrasound-guided intraosseous and intra-articular infiltrations of plasma rich in growth factors (PRGF) in patients with moderate and severe knee osteoarthritis (KOA). Seventy-nine patients (30 women and 49 men) with grade 3-4 KOA according to the Kellgren-Lawrence classification participated in the study. All patients were treated with a minimally invasive technique using local anesthesia WALANT (wide-awake local anesthesia no tourniquet) in the ambulatory setting. A PRGF intra-articular infiltration and two intraosseous infiltrations in the tibial plateau and femoral condyle were performed weekly for a total of three sessions. The evaluation of the results was carried out using knee injury and osteoarthritis outcome score (KOOS) at baseline and post-treatment. After a follow-up period of 11 months (median) [interquartile range, 7-14], all the KOOS domains showed statistically significant improvement (p < 0.001). Moreover, 88% of the patients showed a pain reduction of at least 10 points (minimally clinically important improvement) from pre- to post-treatment. Our retrospective study using the in-office procedure of ultrasound-guided combination of intra-articular and intraosseous infiltrations of PRGF is a safe and efficacious approach for the treatment of grade 3-4 knee osteoarthritis.<\/p>\n<\/div>\n<\/div>\n<\/div>\n

Keywords:\u00a0<\/strong>PRGF; intraosseous; osteoarthritis; platelet-rich plasma.[\/vc_column_text][vc_empty_space][vc_column_text]<\/p>\n

Figures<\/h3>\n
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J Clin Med. 2023 Jul 6;12(13):4512.<\/strong>
\nThe aim of this study was to explore and assess office-based ultrasound-guided intraosseous and intra-articular infiltrations of plasma rich in growth factors (PRGF) in patients with moderate and severe knee osteoarthritis (KOA). Seventy-nine patients (30 women and 49 men) with grade 3-4 KOA according to the Kellgren-Lawrence classification participated in the study. All patients were treated with a minimally invasive technique using local anesthesia WALANT (wide-awake local anesthesia no tourniquet) in the ambulatory setting. A PRGF intra-articular infiltration and two intraosseous infiltrations in the tibial plateau and femoral condyle were performed weekly for a total of three sessions. The evaluation of the results was carried out using knee injury and osteoarthritis outcome score (KOOS) at baseline and post-treatment.<\/p>\n","protected":false},"author":2002,"featured_media":40400,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[158],"tags":[],"class_list":["post-40436","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicina-regenerativa-pt-pt"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.btitrainingcenter.com\/pt-pt\/wp-json\/wp\/v2\/posts\/40436","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.btitrainingcenter.com\/pt-pt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.btitrainingcenter.com\/pt-pt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.btitrainingcenter.com\/pt-pt\/wp-json\/wp\/v2\/users\/2002"}],"replies":[{"embeddable":true,"href":"https:\/\/www.btitrainingcenter.com\/pt-pt\/wp-json\/wp\/v2\/comments?post=40436"}],"version-history":[{"count":2,"href":"https:\/\/www.btitrainingcenter.com\/pt-pt\/wp-json\/wp\/v2\/posts\/40436\/revisions"}],"predecessor-version":[{"id":40438,"href":"https:\/\/www.btitrainingcenter.com\/pt-pt\/wp-json\/wp\/v2\/posts\/40436\/revisions\/40438"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.btitrainingcenter.com\/pt-pt\/wp-json\/wp\/v2\/media\/40400"}],"wp:attachment":[{"href":"https:\/\/www.btitrainingcenter.com\/pt-pt\/wp-json\/wp\/v2\/media?parent=40436"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.btitrainingcenter.com\/pt-pt\/wp-json\/wp\/v2\/categories?post=40436"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.btitrainingcenter.com\/pt-pt\/wp-json\/wp\/v2\/tags?post=40436"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}