
{"id":40688,"date":"2023-02-27T12:02:17","date_gmt":"2023-02-27T11:02:17","guid":{"rendered":"https:\/\/www.btitrainingcenter.com\/efficacy-of-platelet-rich-plasma-in-women-with-a-history-of-embryo-transfer-failure-a-systematic-review-and-meta-analysis-with-trial-sequential-analysis\/"},"modified":"2025-07-21T12:32:40","modified_gmt":"2025-07-21T11:32:40","slug":"efficacy-of-platelet-rich-plasma-in-women-with-a-history-of-embryo-transfer-failure-a-systematic-review-and-meta-analysis-with-trial-sequential-analysis","status":"publish","type":"post","link":"https:\/\/www.btitrainingcenter.com\/fr\/efficacy-of-platelet-rich-plasma-in-women-with-a-history-of-embryo-transfer-failure-a-systematic-review-and-meta-analysis-with-trial-sequential-analysis\/","title":{"rendered":"Efficacy of Platelet-Rich Plasma in Women with a History of Embryo Transfer Failure: A Systematic Review and Meta-Analysis with Trial Sequential Analysis"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row content_text_aligment=&#8221;left&#8221; row_background_lines=&#8221;no&#8221;][vc_column][vc_column_text css=&#8221;&#8221;]<\/p>\n<h3 class=\"title\">Abstract<\/h3>\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\n<p>Assisted reproductive technology (ART) is used to enhance pregnancy in infertile women. In this technique, the eggs are removed from the ovary and fertilized and injected with sperm to make embryos. Unfortunately, embryo implantation failures still occur in many of these women. Platelet-rich plasma (PRP) therapies use a patient&#8217;s own platelets to promote tissue healing and growth, including endometrium. The growth factors provided by the platelets play a criterial role on the regenerative ability of PRP. In the last years, PRP treatments have been gaining a lot of popularity to treat women with repeated ART failures. In this study, we collected and summarized all information published in the scientific literature to assess the evidence of the PRP effect on pregnancy. We only considered randomized controlled trials (RCT), a type of study designed to be unbiased and considered at the highest level of evidence. Our analysis indicates that PRP therapies might be an effective treatment in cases of poor responsiveness to conventional ART. However, additional studies (well-designed) are necessary to confirm this beneficial effect of PRP.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<p><strong class=\"sub-title\">Keywords:\u00a0<\/strong>biochemical pregnancy; clinical pregnancy; platelet-rich plasma; repeated implantation rate; thin endometrium.[\/vc_column_text][vc_empty_space][vc_column_text]<\/p>\n<h3>Figures<\/h3>\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\n<p>[\/vc_column_text][vc_empty_space][\/vc_column][\/vc_row][vc_row content_placement=&#8221;middle&#8221; content_text_aligment=&#8221;center&#8221;][vc_column]<div class=\"qodef-image-gallery qodef-grid-list qodef-disable-bottom-space  qodef-ig-grid-type qodef-four-columns qodef-tiny-space  qodef-image-behavior-lightbox\">\n\t<div class=\"qodef-ig-inner qodef-outer-space\">\n\t\t\t\t\t<div class=\"qodef-ig-image qodef-item-space\">\n\t\t\t\t<div class=\"qodef-ig-image-inner\">\n\t\t\t\t\t\t\t\t\t\t\t<a itemprop=\"image\" class=\"qodef-ig-lightbox\" href=\"https:\/\/www.btitrainingcenter.com\/wp-content\/uploads\/2021\/08\/bioengineering-10-00303-g001.jpg\" data-rel=\"prettyPhoto[image_gallery_pretty_photo-148]\" title=\"&lt;strong&gt;Figure 1&lt;\/strong&gt; Study selection flow diagram. PRISMA flow diagram of the screening and selection process.\">\n\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.btitrainingcenter.com\/wp-content\/uploads\/2021\/08\/bioengineering-10-00303-g001-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" \/>\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t<div class=\"qodef-ig-image qodef-item-space\">\n\t\t\t\t<div class=\"qodef-ig-image-inner\">\n\t\t\t\t\t\t\t\t\t\t\t<a itemprop=\"image\" class=\"qodef-ig-lightbox\" href=\"https:\/\/www.btitrainingcenter.com\/wp-content\/uploads\/2021\/08\/bioengineering-10-00303-g002.jpg\" data-rel=\"prettyPhoto[image_gallery_pretty_photo-148]\" title=\"&lt;strong&gt;Figure 2&lt;\/strong&gt; Quality assessment of the included RCTs. (A) Risk of bias summary: review authors\u2019 judgments about each risk of bias item for each included study: (+), low risk of bias; (\u2212): high risk of bias; (?): unclear risk of bias. (B) Risk of bias graph: review authors\u2019 judgments about each risk of bias item presented as percentages across all included studies.\">\n\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.btitrainingcenter.com\/wp-content\/uploads\/2021\/08\/bioengineering-10-00303-g002-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" \/>\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t<div class=\"qodef-ig-image qodef-item-space\">\n\t\t\t\t<div class=\"qodef-ig-image-inner\">\n\t\t\t\t\t\t\t\t\t\t\t<a itemprop=\"image\" class=\"qodef-ig-lightbox\" href=\"https:\/\/www.btitrainingcenter.com\/wp-content\/uploads\/2021\/08\/bioengineering-10-00303-g003a.jpg\" data-rel=\"prettyPhoto[image_gallery_pretty_photo-148]\" title=\"&lt;strong&gt;Figure 3a&lt;\/strong&gt; Meta-analysis of the studies evaluating (A) clinical pregnancy rate, (B) implantation rate, (C) biochemical pregnancy rate, (D) live-birth rate, and (E) miscarriage rate. CI: confidence interval; PRP: platelet-rich plasma. Studies with high-risk bias were excluded.\">\n\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.btitrainingcenter.com\/wp-content\/uploads\/2021\/08\/bioengineering-10-00303-g003a-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" \/>\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t<div class=\"qodef-ig-image qodef-item-space\">\n\t\t\t\t<div class=\"qodef-ig-image-inner\">\n\t\t\t\t\t\t\t\t\t\t\t<a itemprop=\"image\" class=\"qodef-ig-lightbox\" href=\"https:\/\/www.btitrainingcenter.com\/wp-content\/uploads\/2021\/08\/bioengineering-10-00303-g003b.jpg\" data-rel=\"prettyPhoto[image_gallery_pretty_photo-148]\" title=\"&lt;strong&gt;Figure 3b&lt;\/strong&gt; Meta-analysis of the studies evaluating (A) clinical pregnancy rate, (B) implantation rate, (C) biochemical pregnancy rate, (D) live-birth rate, and (E) miscarriage rate. CI: confidence interval; PRP: platelet-rich plasma. Studies with high-risk bias were excluded.\">\n\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.btitrainingcenter.com\/wp-content\/uploads\/2021\/08\/bioengineering-10-00303-g003b-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" \/>\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t<div class=\"qodef-ig-image qodef-item-space\">\n\t\t\t\t<div class=\"qodef-ig-image-inner\">\n\t\t\t\t\t\t\t\t\t\t\t<a itemprop=\"image\" class=\"qodef-ig-lightbox\" href=\"https:\/\/www.btitrainingcenter.com\/wp-content\/uploads\/2021\/08\/bioengineering-10-00303-g004.jpg\" data-rel=\"prettyPhoto[image_gallery_pretty_photo-148]\" title=\"&lt;strong&gt;Figure 4&lt;\/strong&gt; Trial sequential analysis for (A) clinical pregnancy rate, (B) implantation pregnancy rate, (C) biochemical pregnancy rate, (D) live birth rate and (E) miscarriage rate in recurrent implantation failure (RIF) studies. Studies with high-risk bias were excluded.\">\n\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.btitrainingcenter.com\/wp-content\/uploads\/2021\/08\/bioengineering-10-00303-g004-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" \/>\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<\/div>\n<\/div>[vc_empty_space height=&#8221;50px&#8221;][\/vc_column][\/vc_row][vc_row][vc_column]<a itemprop=\"url\" href=\"https:\/\/www.btitrainingcenter.com\/wp-content\/uploads\/2021\/08\/28-bioengineering-10-00303.pdf\" target=\"_blank\"  class=\"qodef-btn qodef-btn-medium qodef-btn-solid btnWebRosa2\"  >\n    <span class=\"qodef-btn-text\">T\u00e9l\u00e9charger l&#039;article<\/span>\n    <\/a>[\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n<\/div>\n<p>[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p><strong>Bioengineering (Basel). 2023 Feb 27;10(3):303. <\/strong><br \/>\nAssisted reproductive technology (ART) is used to enhance pregnancy in infertile women. In this technique, the eggs are removed from the ovary and fertilized and injected with sperm to make embryos. Unfortunately, embryo implantation failures still occur in many of these women. Platelet-rich plasma (PRP) therapies use a patient&#8217;s own platelets to promote tissue healing and growth, including endometrium. The growth factors provided by the platelets play a criterial role on the regenerative ability of PRP. In the last years, PRP treatments have been gaining a lot of popularity to treat women with repeated ART failures. <\/p>\n","protected":false},"author":2002,"featured_media":40637,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[155],"tags":[],"class_list":["post-40688","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medecine-regenerative"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.btitrainingcenter.com\/fr\/wp-json\/wp\/v2\/posts\/40688","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.btitrainingcenter.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.btitrainingcenter.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.btitrainingcenter.com\/fr\/wp-json\/wp\/v2\/users\/2002"}],"replies":[{"embeddable":true,"href":"https:\/\/www.btitrainingcenter.com\/fr\/wp-json\/wp\/v2\/comments?post=40688"}],"version-history":[{"count":1,"href":"https:\/\/www.btitrainingcenter.com\/fr\/wp-json\/wp\/v2\/posts\/40688\/revisions"}],"predecessor-version":[{"id":40689,"href":"https:\/\/www.btitrainingcenter.com\/fr\/wp-json\/wp\/v2\/posts\/40688\/revisions\/40689"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.btitrainingcenter.com\/fr\/wp-json\/wp\/v2\/media\/40637"}],"wp:attachment":[{"href":"https:\/\/www.btitrainingcenter.com\/fr\/wp-json\/wp\/v2\/media?parent=40688"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.btitrainingcenter.com\/fr\/wp-json\/wp\/v2\/categories?post=40688"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.btitrainingcenter.com\/fr\/wp-json\/wp\/v2\/tags?post=40688"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}