
{"id":20335,"date":"2021-07-02T09:00:59","date_gmt":"2021-07-02T09:00:59","guid":{"rendered":"https:\/\/dev2.btitrainingcenter.com\/use-of-plasma-rich-in-growth-factors-and-regenerating-agent-matrix-for-the-treatment-of-corneal-diseases\/"},"modified":"2025-03-17T14:23:10","modified_gmt":"2025-03-17T13:23:10","slug":"use-of-plasma-rich-in-growth-factors-and-regenerating-agent-matrix-for-the-treatment-of-corneal-diseases","status":"publish","type":"post","link":"https:\/\/www.btitrainingcenter.com\/fr\/use-of-plasma-rich-in-growth-factors-and-regenerating-agent-matrix-for-the-treatment-of-corneal-diseases\/","title":{"rendered":"Use of Plasma Rich in Growth Factors and ReGeneraTing Agent Matrix for the Treatment of Corneal Diseases"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row content_text_aligment=&#8221;left&#8221; row_background_lines=&#8221;no&#8221;][vc_column][vc_column_text]<\/p>\n<h3 class=\"title\">Abstract<\/h3>\n<div id=\"enc-abstract\" class=\"abstract-content selected\">\n<div id=\"enc-abstract\" class=\"abstract-content selected\">\n<div id=\"enc-abstract\" class=\"abstract-content selected\">\n<p>This study aimed to investigate the use of Plasma Rich in Growth Factors (PRGF) associated with tissue ReGeneraTing Agent (RGTA) drops for the treatment of noninfectious corneal ulcers. RGTA treatment was applied (one drop every two days); however, if ulcer closure was not achieved, PRGF eye drops treatment was added (four times\/day). The time taken to reach the ulcer closure, the Best Corrected Visual Acuity (BCVA), intraocular pressure (IOP), Visual Analog Scale (VAS, in terms of frequency and severity of symptoms), and Ocular Surface Disease Index (OSDI) were evaluated. Seventy-four patients (79 eyes) were included, and the mean age was 56.8 \u00b1 17.3 years. The neurotrophic corneal ulcer was the most frequent disorder (<i>n<\/i>\u00a0= 27, 34.2%), mainly for herpes virus (<i>n<\/i>\u00a0= 15, 19.0%). The time of PRGF eye drops treatment associated with the RGTA matrix was 4.2 \u00b1 2.2 (1.5-9.0) months, and the follow-up period was 44.9 \u00b1 31.5 months. The ulcer closure was achieved in 76 eyes (96.2%). BCVA, VAS and OSDI improved from the baseline (<i>p<\/i>\u00a0&lt; 0.001), and IOP remained unchanged (<i>p<\/i>\u00a0= 0.665). RGTA and PRGF in noninfectious ulcers were effective and could be a therapeutic alternative for this type of corneal disease.<\/p>\n<\/div>\n<p><strong class=\"sub-title\">Keywords:\u00a0<\/strong>PRGF; PRP; RGTA matrix; corneal ulcers; ocular surface diseases.<\/p>\n<\/div>\n<\/div>\n<p>[\/vc_column_text][vc_empty_space][vc_column_text]<\/p>\n<h3>Figures<\/h3>\n<p>[\/vc_column_text][vc_empty_space][\/vc_column][\/vc_row][vc_row content_placement=&#8221;middle&#8221; content_text_aligment=&#8221;center&#8221;][vc_column]<div class=\"qodef-image-gallery qodef-grid-list qodef-disable-bottom-space  qodef-ig-grid-type qodef-four-columns qodef-tiny-space  qodef-image-behavior-lightbox\">\n\t<div class=\"qodef-ig-inner qodef-outer-space\">\n\t\t\t\t\t<div class=\"qodef-ig-image qodef-item-space\">\n\t\t\t\t<div class=\"qodef-ig-image-inner\">\n\t\t\t\t\t\t\t\t\t\t\t<a itemprop=\"image\" class=\"qodef-ig-lightbox\" href=\"https:\/\/www.btitrainingcenter.com\/wp-content\/uploads\/2021\/08\/vision-05-00034-g001.jpeg\" data-rel=\"prettyPhoto[image_gallery_pretty_photo-123]\" title=\"&lt;strong&gt;Figure 01&lt;\/strong&gt; Results of the primary outcome measures before and after treatment with PRGF eye drops and RGTA. (A): Dry eye disease (DED). (B): Percentage of the corneal defect. (C): Corneal staining area. (D): Corneal staining density. * Statistically significant differences (p &lt; 0.05) before versus after treatment with PRGF and RGTA.\">\n\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.btitrainingcenter.com\/wp-content\/uploads\/2021\/08\/vision-05-00034-g001-200x200.jpeg\" alt=\"\" width=\"200\" height=\"200\" \/>\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t<div class=\"qodef-ig-image qodef-item-space\">\n\t\t\t\t<div class=\"qodef-ig-image-inner\">\n\t\t\t\t\t\t\t\t\t\t\t<a itemprop=\"image\" class=\"qodef-ig-lightbox\" href=\"https:\/\/www.btitrainingcenter.com\/wp-content\/uploads\/2021\/08\/vision-05-00034-g002.jpeg\" data-rel=\"prettyPhoto[image_gallery_pretty_photo-123]\" title=\"&lt;strong&gt;Figure 02&lt;\/strong&gt; Results of the secondary outcome measured before and after treatment with PRGF eye drops and RGTA. (A): Best-corrected visual acuity (BCVA). (B): Ocular surface disease index (OSDI). (C): Visual analog scale (VAS) frequency, and (D): VAS severity. * Statistically significant differences (p &lt; 0.05) before versus after treatment with PRGF and RGTA.\">\n\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.btitrainingcenter.com\/wp-content\/uploads\/2021\/08\/vision-05-00034-g002-200x200.jpeg\" alt=\"\" width=\"200\" height=\"200\" \/>\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t<div class=\"qodef-ig-image qodef-item-space\">\n\t\t\t\t<div class=\"qodef-ig-image-inner\">\n\t\t\t\t\t\t\t\t\t\t\t<a itemprop=\"image\" class=\"qodef-ig-lightbox\" href=\"https:\/\/www.btitrainingcenter.com\/wp-content\/uploads\/2021\/08\/vision-05-00034-g003.jpeg\" data-rel=\"prettyPhoto[image_gallery_pretty_photo-123]\" title=\"&lt;strong&gt;Figure 03&lt;\/strong&gt; Corneal ulcer of a patient with Salzmann\u2019s nodular degeneration treated with PRGF eye drops and RGTA. (A): Baseline situation. (B): Corneal image obtained after one month of follow-up, the corneal ulcer is under closure process. (C): Complete corneal ulcer closure after three cycles of PRGF eye drops. (D): OCT-SA image, restoration of corneal integrity maintained along the follow-up period (80.5 months).\">\n\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.btitrainingcenter.com\/wp-content\/uploads\/2021\/08\/vision-05-00034-g003-200x200.jpeg\" alt=\"\" width=\"200\" height=\"200\" \/>\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t<div class=\"qodef-ig-image qodef-item-space\">\n\t\t\t\t<div class=\"qodef-ig-image-inner\">\n\t\t\t\t\t\t\t\t\t\t\t<a itemprop=\"image\" class=\"qodef-ig-lightbox\" href=\"https:\/\/www.btitrainingcenter.com\/wp-content\/uploads\/2021\/08\/vision-05-00034-g004.jpeg\" data-rel=\"prettyPhoto[image_gallery_pretty_photo-123]\" title=\"&lt;strong&gt;Figure 04&lt;\/strong&gt; Patient with meta-herpetic corneal ulcer treated with PRGF and RGTA. (A): Baseline image. (B): Acute post-infection neurotrophic corneal ulcer. (C): Complete corneal ulcer closure after two cycles of PRGF eye drops. The corneal closure was stable throughout the follow-up (38.3 months).\">\n\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.btitrainingcenter.com\/wp-content\/uploads\/2021\/08\/vision-05-00034-g004-200x200.jpeg\" alt=\"\" width=\"200\" height=\"200\" \/>\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<\/div>\n<\/div>[vc_empty_space height=&#8221;50px&#8221;][\/vc_column][\/vc_row][vc_row][vc_column]<a itemprop=\"url\" href=\"\/wp-content\/uploads\/2021\/08\/vision-05-00034.pdf\" target=\"_blank\"  class=\"qodef-btn qodef-btn-medium qodef-btn-solid btnWebRosa2\"  >\n    <span class=\"qodef-btn-text\">T\u00e9l\u00e9charger l&#039;article<\/span>\n    <\/a>[\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p><strong>Vision (Basel). 2021 Jul 2;5(3):34.<\/strong> This study aimed to investigate the use of Plasma Rich in Growth Factors (PRGF) associated with tissue ReGeneraTing Agent (RGTA) drops for the treatment of noninfectious corneal ulcers<\/p>\n","protected":false},"author":1,"featured_media":19755,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[155],"tags":[405,406,407,408],"class_list":["post-20335","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medecine-regenerative","tag-apnea-fr","tag-implantologia-fr","tag-medicina-fr","tag-salud-fr"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.btitrainingcenter.com\/fr\/wp-json\/wp\/v2\/posts\/20335","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.btitrainingcenter.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.btitrainingcenter.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.btitrainingcenter.com\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.btitrainingcenter.com\/fr\/wp-json\/wp\/v2\/comments?post=20335"}],"version-history":[{"count":1,"href":"https:\/\/www.btitrainingcenter.com\/fr\/wp-json\/wp\/v2\/posts\/20335\/revisions"}],"predecessor-version":[{"id":36913,"href":"https:\/\/www.btitrainingcenter.com\/fr\/wp-json\/wp\/v2\/posts\/20335\/revisions\/36913"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.btitrainingcenter.com\/fr\/wp-json\/wp\/v2\/media\/19755"}],"wp:attachment":[{"href":"https:\/\/www.btitrainingcenter.com\/fr\/wp-json\/wp\/v2\/media?parent=20335"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.btitrainingcenter.com\/fr\/wp-json\/wp\/v2\/categories?post=20335"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.btitrainingcenter.com\/fr\/wp-json\/wp\/v2\/tags?post=20335"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}