{"id":29426,"date":"2022-09-19T15:39:11","date_gmt":"2022-09-19T14:39:11","guid":{"rendered":"https:\/\/www.btitrainingcenter.com\/?p=29426"},"modified":"2025-03-05T12:17:02","modified_gmt":"2025-03-05T11:17:02","slug":"unravelling-alveolar-bone-regeneration-ability-of-platelet-rich-plasma-a-systematic-review-with-meta-analysis","status":"publish","type":"post","link":"https:\/\/www.btitrainingcenter.com\/en\/unravelling-alveolar-bone-regeneration-ability-of-platelet-rich-plasma-a-systematic-review-with-meta-analysis\/","title":{"rendered":"Unravelling Alveolar Bone Regeneration Ability of Platelet-Rich Plasma: A Systematic Review with Meta-Analysis"},"content":{"rendered":"

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Abstract<\/h3>\n
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Background: <\/strong>This systematic review aims to evaluate the efficacy of the available platelet-rich plasma (PRP) products and composition to regenerate alveolar bone after tooth extraction.<\/p>\n

Methods: <\/strong>PubMed, Cochrane Central Register of Controlled Trials, and EBSCO databases were searched up to 2 July 2021. Only randomized clinical trials using leukocyte-rich plasma (L-PRP) or pure-platelet rich plasma (P-PRP) for bone regeneration in alveolar ridge preservation were selected. The following outcomes were considered: (1) new bone formation (primary outcome) and (2) bone density (secondary outcome). A meta-analysis for PRP, P-PRP, and L-PRP using a fixed effect model was performed with Review Manager 5.4 software. Overall evidence was qualified using GRADE.<\/p>\n

Results: <\/strong>Six randomized clinical trials from 2639 unique articles initially identified met the inclusion criteria. The meta-analysis showed a significant effect of the P-PRP on the outcome of new bone formation (SMD, 1.44; 95% CI, 0.84 to 2.03) for P-PRP treatment. No information was retrieved for L-PRP. A statistically significant difference was also observed in the P-PRP group for bone density outcome (SMD, 1.24; 95% CI, 0.81 to 1.68). The L-PRP treated sockets also showed higher bone density (SMD, 0.88; 95% CI, 0.31 to 1.45) in comparison to control sockets. The quality of evidence was moderate for both outcomes in the P-PRP group and low for the L-PRP group.<\/p>\n

Conclusions: <\/strong>Despite the limitations of the included studies, our data suggest that P-PRP, in comparison to unassisted healing, can improve alveolar bone regenerative potential. However, more high-quality clinical studies are needed.<\/p>\n<\/div>\n<\/div>\n<\/div>\n

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Bioengineering (Basel). 2022 Sep 27;9(10):506.<\/strong> This systematic review aims to evaluate the efficacy of the available platelet-rich plasma (PRP) products and composition to regenerate alveolar bone after tooth extraction<\/p>\n","protected":false},"author":2002,"featured_media":29407,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[150],"tags":[],"class_list":["post-29426","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-regenerative-medicine"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.btitrainingcenter.com\/en\/wp-json\/wp\/v2\/posts\/29426","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.btitrainingcenter.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.btitrainingcenter.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.btitrainingcenter.com\/en\/wp-json\/wp\/v2\/users\/2002"}],"replies":[{"embeddable":true,"href":"https:\/\/www.btitrainingcenter.com\/en\/wp-json\/wp\/v2\/comments?post=29426"}],"version-history":[{"count":1,"href":"https:\/\/www.btitrainingcenter.com\/en\/wp-json\/wp\/v2\/posts\/29426\/revisions"}],"predecessor-version":[{"id":36500,"href":"https:\/\/www.btitrainingcenter.com\/en\/wp-json\/wp\/v2\/posts\/29426\/revisions\/36500"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.btitrainingcenter.com\/en\/wp-json\/wp\/v2\/media\/29407"}],"wp:attachment":[{"href":"https:\/\/www.btitrainingcenter.com\/en\/wp-json\/wp\/v2\/media?parent=29426"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.btitrainingcenter.com\/en\/wp-json\/wp\/v2\/categories?post=29426"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.btitrainingcenter.com\/en\/wp-json\/wp\/v2\/tags?post=29426"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}