{"id":47762,"date":"2025-03-13T08:47:47","date_gmt":"2025-03-13T07:47:47","guid":{"rendered":"https:\/\/www.btitrainingcenter.com\/endometrial-infusion-with-plasma-rich-in-growth-factors-prgf-in-ivf-cycles-randomized-clinical-trial-in-very-thin-endometrium-and-observational-uncontrolled-follow-up-after-the-randomized-clinical\/"},"modified":"2026-04-09T17:11:19","modified_gmt":"2026-04-09T16:11:19","slug":"endometrial-infusion-with-plasma-rich-in-growth-factors-prgf-in-ivf-cycles-randomized-clinical-trial-in-very-thin-endometrium-and-observational-uncontrolled-follow-up-after-the-randomized-clinical","status":"publish","type":"post","link":"https:\/\/www.btitrainingcenter.com\/de\/endometrial-infusion-with-plasma-rich-in-growth-factors-prgf-in-ivf-cycles-randomized-clinical-trial-in-very-thin-endometrium-and-observational-uncontrolled-follow-up-after-the-randomized-clinical\/","title":{"rendered":"Endometrial Infusion with Plasma Rich in Growth Factors (PRGF) in IVF Cycles: Randomized Clinical Trial in Very Thin Endometrium and Observational Uncontrolled Follow-Up After the Randomized Clinical Trial"},"content":{"rendered":"

[vc_row gap=”20″ content_text_aligment=”left” row_background_lines=”no”][vc_column width=”2\/3″][vc_column_text css=””]<\/p>\n

Abstract<\/h3>\n
\n
\n

Objectives:\u00a0<\/strong>To assess if the instillation of plasma rich growth factors (PRGFs) improves endometrial thickness (EMT) in frozen embryo cycles performed under hormone treatment where the endometrium was very thin (\u22645 mm).<\/p>\n

Methods:\u00a0<\/strong>First, a randomized controlled trial (RCT) was performed comparing women only receiving an increase in estrogen therapy (n = 9) and women receiving both the increase in estrogen therapy and three instillations of PRGF (n = 13). The second part of the study consisted of a prospective observational follow-up of the patients included in the RCT (for 1-3 months in the study group, and for 1-6 months in the control group).<\/p>\n

Results:\u00a0<\/strong>In the RCT, there was an increase in EMT in both the PRGF and control groups. However, the increase was significantly higher in the PRGF group (1.30 \u00b1 0.67 mm) compared to the control group (0.58 \u00b1 0.51 mm). In the PRGF group, 23% achieved an EMT of 7 mm compared to 0% in the control group. There were 2 pregnancies in the PRGF group resulting from the 3 transfers performed in that group. No transfer was carried out in the control group. There was a significant increase in EMT 1-3 months after the PRGF cycle. The live birth rate per transfer was 20% in the cycles following the PRGF cycles, whereas it was 30% per starting woman. For women in the control group who later underwent PRGF, the LBR was 57.1%.<\/p>\n

Conclusions:\u00a0<\/strong>PRGF instillation in cases of very thin endometrium increases EMT moderately. It is suggested that the beneficial effect of PRGF may persist for 1-3 cycles after instillation.<\/p>\n<\/div>\n

Keywords:\u00a0<\/strong>PRGF; PRP; endometrial thickness; live birth rates; pregnancy rates; thin endometrium<\/p>\n<\/div>\n

[\/vc_column_text][vc_empty_space][vc_column_text]<\/p>\n

Figures<\/h3>\n

[\/vc_column_text][vc_empty_space][\/vc_column][vc_column width=”1\/4″ css=”.vc_custom_1775750056684{margin-top: 80px !important;margin-right: 5% !important;margin-left: 30px !important;padding-right: 20px !important;padding-bottom: 20px !important;padding-left: 20px !important;background-color: #F6F6F6 !important;border-radius: 25px !important;}”]

[vc_column_text css=””]Zur Brosch\u00fcre von BTI:<\/em>[\/vc_column_text][vc_single_image image=”47748″ img_size=”medium” alignment=”center” onclick=”custom_link” img_link_target=”_blank” css=”” link=”https:\/\/www.btitrainingcenter.com\/wp-content\/uploads\/2021\/08\/2.-USA_VERY_THIN_ENDOMETRIUM.pdf”]\n Zur Brosch\u00fcre<\/span>\n <\/a><\/div><\/div>[\/vc_column][\/vc_row][vc_row content_placement=”middle” content_text_aligment=”center”][vc_column]
\n\t
\n\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<\/div>\n<\/div>[vc_empty_space height=”50px”][\/vc_column][\/vc_row][vc_row][vc_column]\n Artikel herunterladen<\/span>\n <\/a>[\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

J Clin Med. 2025 Mar 13;14(6):1952.<\/strong>
\nTo assess if the instillation of plasma rich growth factors (PRGFs) improves endometrial thickness (EMT) in frozen embryo cycles performed under hormone treatment where the endometrium was very thin (\u22645 mm).<\/p>\n","protected":false},"author":2002,"featured_media":42058,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[156],"tags":[],"class_list":["post-47762","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-regenerative-medizin"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.btitrainingcenter.com\/de\/wp-json\/wp\/v2\/posts\/47762","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.btitrainingcenter.com\/de\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.btitrainingcenter.com\/de\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.btitrainingcenter.com\/de\/wp-json\/wp\/v2\/users\/2002"}],"replies":[{"embeddable":true,"href":"https:\/\/www.btitrainingcenter.com\/de\/wp-json\/wp\/v2\/comments?post=47762"}],"version-history":[{"count":2,"href":"https:\/\/www.btitrainingcenter.com\/de\/wp-json\/wp\/v2\/posts\/47762\/revisions"}],"predecessor-version":[{"id":47764,"href":"https:\/\/www.btitrainingcenter.com\/de\/wp-json\/wp\/v2\/posts\/47762\/revisions\/47764"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.btitrainingcenter.com\/de\/wp-json\/wp\/v2\/media\/42058"}],"wp:attachment":[{"href":"https:\/\/www.btitrainingcenter.com\/de\/wp-json\/wp\/v2\/media?parent=47762"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.btitrainingcenter.com\/de\/wp-json\/wp\/v2\/categories?post=47762"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.btitrainingcenter.com\/de\/wp-json\/wp\/v2\/tags?post=47762"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}